The twelve boxes of Africa Bureau Papers containing the material relevant to those countries formerly known as the High Commission Territories or the South African Protectorates (Lesotho, Botswana, and Eswatini), MSS. Afr. s. 1681/218-229, are, like the South African section, arranged according to subject matter. Additionally, they have a fourfold division according to territory. Thus, the first and last boxes of this section, MSS. Afr. s. 1681/218 and MSS. Afr. s. 1681/229, hold material common to all three countries. MSS. Afr. s. 1681/219-221 contain material pertaining, in general, only to Basutoland (Lesotho), MSS. Afr. s. 1681/222-227 contain material related similarly to Bechuanaland (Botswana), and MSS. Afr. s. 1681/228 is devoted to Swaziland (Eswatini).

The predominant theme in the early papers of this section is the relationship of the three territories with the Union of South Africa, though all four sub-sections are concerned with their political and economic development. Therefore, much of MSS. Afr. s. 1681/218 concerns the High Commission Territories' objection to any proposals to transfer them to the administration of the Union of South Africa. The Bechuanaland (Botswana) sub-section contains a considerable amount of material which arose from the friendship of Michael Scott and Mary Benson with Tshekedi Khama over many years and, later, with his nephew Sir Seretse Khama and his wife Ruth. Thus, Tshekedi Khama's attempts to introduce social and economic reforms into Bechuanaland (Botswana) and the constitutional dispute that resulted in exile for him and for Seretse are both well-documented. Legal ownership of mineral rights in Bechuanaland (Botswana) and Swaziland (Eswatini), agricultural development in the Bangkok Delta, and the growth of popular political parties are the other major subjects for this region which interested the Africa Bureau over the years. Correspondence reached the Executive Committee from a number of personal contacts and, as the different political parties emerged, their leaders also communicated with the Bureau.